Vitamin B12 (Cyanocobalamin) — Pharma Raw Material Supplier, Hyderabad

Surravi Phharma supplies Cyanocobalamin (Vitamin B12) in IP, BP, EP, and USP grades in Hyderabad. Available in 100 g, 500 g, and 1 kg packaging due to the high potency of this raw material (NLT 96% assay). Used in B-complex tablets, injectable preparations, and vegan supplement formulations. Call +91 8008002576 for pricing and COA.

Cyanocobalamin is the synthetic, most stable form of Vitamin B12 used in pharmaceutical formulations. It must be converted in the body to the active coenzyme forms — Methylcobalamin and Adenosylcobalamin. Methylcobalamin is the neurologically active form that crosses the blood-brain barrier more readily, preferred in formulations targeting neuropathy and cognitive health. Methylcobalamin is less stable and more expensive than Cyanocobalamin. For standard B-complex deficiency replacement, Cyanocobalamin is equally effective. For neuropathy-targeted nutraceuticals, Methylcobalamin is preferred.

Vitamin B12 is found almost exclusively in animal-derived foods (meat, fish, dairy, eggs). Strict vegetarians and vegans who consume no animal products will develop B12 deficiency over time — typically within 3–5 years as body stores are depleted. B12 deficiency causes megaloblastic anaemia, irreversible neurological damage, and elevated homocysteine. Vegetarian and vegan populations in India are estimated to have B12 deficiency rates of 40–80%, making B12 supplementation a major preventive health priority. Cyanocobalamin is the standard supplement form for this population.

Oral Vitamin B12 absorption is complex. At physiological doses (1–2 mcg), absorption is via Intrinsic Factor (IF) — a stomach glycoprotein — with approximately 50% bioavailability. Intrinsic Factor has a saturable capacity of ~1.5 mcg per meal. At pharmacological doses (500–1000 mcg), approximately 1% is absorbed passively without IF — giving absolute absorbed amounts of 5–10 mcg. This passive absorption mechanism is the basis for high-dose oral B12 supplementation (500–1000 mcg/day) being an effective alternative to B12 injections even in patients with IF deficiency (pernicious anaemia).

For prevention and maintenance in vegetarians: 25–250 mcg/day oral. For mild deficiency correction: 500–1000 mcg/day oral Cyanocobalamin. For pernicious anaemia or malabsorption: 1000 mcg/day oral (high-dose passive absorption) or 1000 mcg IM injection (Cyanocobalamin or Hydroxocobalamin) initially daily for 1 week, then weekly for 4 weeks, then monthly for life. Injectable B12 requires pharmaceutical-grade Cyanocobalamin meeting injectable-specification purity and bacterial endotoxin limits.