Vitamin B1 (Thiamine HCl) — Pharma Raw Material Supplier, Hyderabad
Product Overview
Vitamin B1 (Thiamine Hydrochloride) is a water-soluble B-vitamin essential for carbohydrate metabolism and nerve function. It is a key ingredient in B-complex pharmaceutical preparations, multivitamin formulations, and neurological health supplements.
Specifications
| CAS Number | 67-03-8 |
| Molecular Formula | C₁₂H₁₇ClN₄OS·HCl |
| Molecular Weight | 337.27 g/mol |
| Appearance | White crystalline powder |
| Assay | 98.0–101.0% |
| Loss on Drying | NMT 5.0% |
| Grades | IP / BP / EP / USP |
| Packaging | 25 kg HDPE bags |
Applications
- B-complex vitamin pharmaceutical formulations
- Neurological health supplements
- Multivitamin tablets and capsules
- IV nutrition and TPN formulations
- Nutritional deficiency treatment
- Energy metabolism support supplements
Why Source from Surravi Phharma?
- Ready stock maintained in our centralised AC warehouse, Hyderabad
- IP / BP / EP / USP grades available
- Complete documentation: COA, MSDS, Regulatory certifications
- Flexible quantities — lab scale to bulk commercial
- Prompt delivery with pan India logistics support
Frequently Asked Questions
Where can I buy Thiamine HCl (Vitamin B1) IP/USP pharma grade in Hyderabad?
Surravi Phharma supplies Vitamin B1 (Thiamine Hydrochloride) in IP, BP, EP, and USP grades in Hyderabad with ready stock. Used in B-complex tablets, neurological support preparations, and TPN parenteral formulations. Call +91 8008002576 for bulk pricing, COA, and MSDS.
What is the difference between Thiamine HCl and Thiamine Mononitrate for pharmaceutical use?
Thiamine Hydrochloride (HCl) and Thiamine Mononitrate are two salt forms of Vitamin B1. Thiamine HCl is more soluble in water (1 g/mL), making it preferred for aqueous liquid formulations, injections, and oral liquids. Thiamine Mononitrate is less hygroscopic and more stable in solid dosage forms — preferred for tablets and premixes. Both are approved in IP/BP/USP. The HCl form is more common in pharmaceutical injectable preparations; Mononitrate is standard in food fortification and multivitamin tablets.
What are the clinical consequences of Thiamine (Vitamin B1) deficiency?
Severe Thiamine deficiency causes Beriberi — wet Beriberi affecting the cardiovascular system (oedema, heart failure) and dry Beriberi affecting the peripheral nervous system (peripheral neuropathy, muscle weakness). In alcoholic patients, deficiency causes Wernicke's Encephalopathy (confusion, ataxia, eye movement disorders) which can progress to the irreversible Korsakoff syndrome if not treated immediately with IV Thiamine (100–500 mg). This makes pharmaceutical-grade injectable Thiamine a critical emergency medicine.
Is Thiamine HCl compatible with other vitamins in B-complex injectable formulations?
Thiamine HCl is incompatible with several common IV additives and should be checked carefully in parenteral formulations. It is degraded by alkaline pH (above 5) and incompatible with Riboflavin (which photodegrades it), oxidising agents, and some preservatives. In B-complex oral tablets, Thiamine is compatible with all other B-vitamins at standard tablet processing conditions. For liquid multivitamin preparations, stability studies are essential as interactions with riboflavin and pH are common challenges.
What is Benfotiamine and how does it compare to Thiamine HCl?
Benfotiamine is a fat-soluble synthetic derivative of Thiamine that achieves significantly higher tissue concentrations — particularly in neural and vascular tissue — compared to standard water-soluble Thiamine HCl. It is used in diabetic peripheral neuropathy nutraceuticals at 150–300 mg/day, where its superior bioavailability in nerve tissue is clinically relevant. We supply standard Thiamine HCl; Benfotiamine can be quoted separately on request for specialised diabetic supplement formulations.