Aspartame — Pharmaceutical Grade Sweetener Supplier, Hyderabad
Product Overview
Aspartame is an intense artificial sweetener approximately 180–200 times sweeter than sucrose, used in pharmaceutical oral formulations, chewable tablets, oral liquids, and nutraceuticals as a taste-masking agent. It is suitable for diabetic patients and calorie-restricted formulations. Available in IP, BP, EP, and USP grades.
Specifications
| CAS Number | 22839-47-0 |
| Molecular Formula | C₁₄H₁₈N₂O₅ |
| Molecular Weight | 294.30 g/mol |
| Appearance | White crystalline powder |
| Sweetness | 180–200× sucrose |
| Assay | 98.0–102.0% |
| Loss on Drying | NMT 4.5% |
| Grades | IP / BP / EP / USP |
| Packaging | 25 kg HDPE bags |
Applications
- Sweetener in chewable and dispersible tablets
- Taste masking in oral liquid formulations
- Flavouring agent in nutraceutical powders
- Sugar-free confectionery and food products
- Oral care products (toothpaste, mouthwash)
- Effervescent sachets and granules
Why Source from Surravi Phharma?
- Ready stock maintained in our centralised AC warehouse, Hyderabad
- IP / BP / EP / USP grades available
- Complete documentation: COA, MSDS, Regulatory certifications
- Flexible quantities — lab scale to bulk commercial
- Prompt delivery with pan India logistics support
Frequently Asked Questions
Where can I buy Aspartame IP/USP grade for pharmaceutical formulations in Hyderabad?
Surravi Phharma supplies Aspartame in IP, BP, EP, and USP grades in Hyderabad with ready stock. Aspartame is approximately 180–200× sweeter than sucrose and is widely used in chewable tablets, oral liquids, and diabetic-safe pharmaceutical products. Call +91 8008002576 for pricing.
What is the maximum safe use level of Aspartame in pharmaceutical oral formulations?
The WHO acceptable daily intake (ADI) for Aspartame is 40 mg/kg body weight/day. In pharmaceutical oral preparations, Aspartame is typically used at 0.1–0.5% w/w in solid dosage forms and 0.02–0.1% w/v in liquids. At these concentrations, even a 70 kg adult consuming multiple doses per day remains well within the ADI.
Can Aspartame be used in hot-process tablet manufacturing?
Aspartame is thermally unstable above 150°C — it decomposes to diketopiperazine (DKP), which is bitter and reduces sweetness. It is not suitable for hot melt extrusion or processes exceeding 150°C. For direct compression and conventional wet granulation (with drying below 60°C), Aspartame is stable. For heat-intensive processes, Sucralose or Acesulfame-K are better alternatives.
Is Aspartame safe for patients with phenylketonuria (PKU)?
No. Aspartame contains phenylalanine, which is dangerous for patients with phenylketonuria (PKU) — a genetic disorder where phenylalanine cannot be metabolised. Any pharmaceutical or food product containing Aspartame must carry a PKU warning label: 'Contains Phenylalanine.' For PKU-safe formulations, Sucralose or Acesulfame-K must be used instead.
How does Aspartame compare to Sucralose and Acesulfame-K for pharmaceutical use?
Aspartame is calorie-containing (4 kcal/g by weight but negligible at use levels), PKU-restricted, temperature-sensitive, and not ideal for extended liquid shelf life. Sucralose is calorie-free, PKU-safe, heat-stable, and more suitable for liquids. Acesulfame-K is heat-stable and often blended with Aspartame to achieve synergistic sweetness with a cleaner taste profile. Many pharmaceutical oral liquids use a blend of Aspartame and Acesulfame-K.