L-Leucine — BCAA Amino Acid Supplier, Hyderabad
Product Overview
L-Leucine is the most anabolic of the three branched-chain amino acids (BCAAs), directly stimulating muscle protein synthesis via the mTOR signalling pathway. It is the key trigger amino acid in BCAA formulations, widely used in sports nutrition, muscle recovery, anti-sarcopenia, and parenteral amino acid solutions for clinical nutrition.
Specifications
| CAS Number | 61-90-5 |
| Molecular Formula | C₆H₁₃NO₂ |
| Molecular Weight | 131.17 g/mol |
| Appearance | White crystalline powder |
| Assay | 98.5–101.5% |
| Specific Rotation | +14.9° to +16.4° |
| Loss on Drying | NMT 0.3% |
| Grades | IP / BP / EP / USP |
| Packaging | 25 kg HDPE bags |
Applications
- BCAA sports nutrition and muscle building
- Muscle protein synthesis trigger (mTOR activation)
- Anti-sarcopenia supplement for elderly populations
- Parenteral TPN amino acid solutions
- Weight management and satiety supplement blends
- Post-workout and recovery formulations
Why Source from Surravi Phharma?
- Ready stock maintained in our centralised AC warehouse, Hyderabad
- IP / BP / EP / USP grades available
- Complete documentation: COA, MSDS, Regulatory certifications
- Flexible quantities — lab scale to bulk commercial
- Prompt delivery with pan India logistics support
Frequently Asked Questions
Where can I buy L-Leucine BCAA pharma grade in Hyderabad?
Surravi Phharma supplies L-Leucine in IP, BP, EP, and USP grades in Hyderabad with ready stock. L-Leucine is the most anabolic of the three branched-chain amino acids and is a critical raw material for sports nutrition, muscle recovery, and clinical nutrition formulations. Call +91 8008002576 for bulk pricing and documentation.
How does L-Leucine activate muscle protein synthesis through mTOR?
L-Leucine is unique among amino acids in its ability to directly activate the mTOR (mechanistic Target of Rapamycin) signalling pathway — the master regulator of muscle protein synthesis. Leucine acts as a nutrient sensor that signals to the ribosomal machinery to increase protein translation when leucine availability is adequate. This mechanism is why Leucine is called the 'anabolic trigger' amino acid. A threshold intracellular Leucine concentration of approximately 0.7–1.0 mM is required for maximal mTOR activation — achieved with approximately 2.5–3 g of Leucine per dose in most individuals.
What is the standard BCAA ratio (Leucine:Isoleucine:Valine) and why?
The classic BCAA ratio used in sports nutrition is 2:1:1 (Leucine:Isoleucine:Valine). This ratio reflects approximate BCAA composition in human skeletal muscle tissue. Higher Leucine ratios (4:1:1 or even 8:1:1) have become popular based on Leucine's mTOR-activating primacy — the theory being that more Leucine better triggers muscle protein synthesis. However, evidence does not clearly support 4:1:1 superiority over 2:1:1 for overall muscle recovery when total amino acid intake is matched. For a 10 g BCAA serving at 2:1:1: 5 g Leucine + 2.5 g Isoleucine + 2.5 g Valine.
Is L-Leucine useful for preventing muscle loss (sarcopenia) in elderly patients?
Yes. Sarcopenia — age-related muscle loss — is a major healthcare challenge affecting approximately 25% of people over 70 and 50% over 80. Elderly individuals have reduced muscle protein synthesis response to standard meals — a condition called 'anabolic resistance.' Leucine-enriched protein supplements (3–4 g Leucine per serving vs 1–2 g in standard protein) can overcome this anabolic resistance and restore muscle protein synthesis rates closer to those seen in younger people. This is a growing area of evidence-based clinical nutrition with significant demand for high-quality L-Leucine raw material in clinical nutrition product formulations.